both disappointing and concerning, Dr. Klein notes that studies such as this may not tell the entire story. “If you speak to individual physicians, many will tell you that a significant number of patients have become seizure-free on some of the new medications and that seizures in some of the other patients may be less severe and less frequent,” he says. Dr. Klein points to the increasing difficulty to recruit for Phase 2 and 3 studies of new anti-seizure medications—suggesting that fewer patients have severe partial onset seizures—as a reflection of this trend. “This hasn’t been documented in controlled studies, but it’s an impression that is shared by many epileptologists.”