Practical Neurology

November/December 2020

Dementia Innovations

-Naturalistic Driving Measures
-Blood Tests for Alzheimer Disease
-PET Tracer Imaging and Volumetric MRI for Dementia Diagnosis

Featured

Naturalistic Driving Measures

Ganesh M. Babulal, PhD, OTD, and Catherine M. Roe, PhD

Digital Cognitive Assessments for Dementia

Adam M. Staffaroni, PhD; Elena Tsoy, PhD; Jack Taylor, BS; Adam L. Boxer, MD, PhD; and Katherine L. Possin, PhD

Molecular Imaging Biomarkers in Dementia

Brad Dickerson, MD, and Alireza Atri, MD, PhD

Quantitative Structural MRI for Neurocognitive Disorders

Cyrus A. Raji, MD, PhD; Somayeh Meysami, MD; and Mario F. Mendez, MD, PhD

Blood Tests for Alzheimer Disease

Henrik Zetterberg, MD, PhD; Deborah O.T. Alawode, BSc; Ashvini Keshavan, MRCP, PhD; Antoinette O’Connor, MRCPI; Philip S. J. Weston, MRCP, PhD; Ross W. Paterson, MRCP, PhD; Amanda Heslegrave, PhD; Nick C. Fox, MD, FRCP, FMedSci; Michael P. Lunn, FRCP, PhD; and Jonathan M. Schott, MD, FRCP

Neurofilament Light as a Dementia Biomarker

Julio C. Rojas, MD, PhD

Physical and Cognitive Activity for Dementia

Ajay Sood, MD, PhD, and David Bennett, MD

In this issue

Guest Medical Editor's Page

Dementia Innovations

After years in development, many innovations are poised to move into clinical practice.

Nupur Ghoshal, MD, PhD

Cover Focus

Naturalistic Driving Measures

Naturalistic driving measurement serves as a functional marker for preclinical and symptomatic Alzheimer disease.

Ganesh M. Babulal, PhD, OTD, and Catherine M. Roe, PhD

Digital Cognitive Assessments for Dementia

Digital assessments may enhance the efficiency of evaluations in neurology and other clinics.

Adam M. Staffaroni, PhD; Elena Tsoy, PhD; Jack Taylor, BS; Adam L. Boxer, MD, PhD; and Katherine L. Possin, PhD

Molecular Imaging Biomarkers in Dementia

Amyloid and tau PET imaging aids evaluation of patients suspected of having Alzheimer disease or other dementias.

Brad Dickerson, MD, and Alireza Atri, MD, PhD

Quantitative Structural MRI for Neurocognitive Disorders

Alzheimer disease dementia, frontotemporal dementia, and traumatic brain injury can be differentiated with quantitative MRI.

Cyrus A. Raji, MD, PhD; Somayeh Meysami, MD; and Mario F. Mendez, MD, PhD

Blood Tests for Alzheimer Disease

Blood tests for Alzheimer disease are moving toward clinical implementation and interpretation.

Neurofilament Light as a Dementia Biomarker

An emerging versatile blood biomarker may help identify neurodegenerative diseases and help track disease progression and treatment response.

Julio C. Rojas, MD, PhD

Physical and Cognitive Activity for Dementia

There is enough evidence of the neuroprotective effects of physical and cognitive activity to recommend these to patients.

Ajay Sood, MD, PhD, and David Bennett, MD

Case Reports

Challenging Case Report: New-Onset Seizures and Brain Lesions in First Trimester

A woman age 29 and 10 weeks pregnant presented with new-onset seizures and imaging demonstrated previously undiagnosed lesions.

Omar Bushara, BA; Rimas V. Lukas, MD; and Jessica W. Templer, MD

Case Reports: Mitochondrial Neurogastrointestinal Encephalopathy

Mitochondrial neurogastrointestinal encephalopathy syndrome is a rare, treatable cause of adult-onset leukoencephalopathy.

Carlos E.V. Sollero, MD; Hsin-Pin Lin, MD; Miguel Chuquilin, MD; James Wymer, MD; and Aaron M. Carlson, MD

Columns

Smart Business Great Medicine: Voice Assistance

Voice technology is a life-preserver for healthcare.

James Geyer, MD, and Thomas Patton, MD

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Patients & Caregivers

Find Information and tools about Neurological diseases to assist patients and caregivers.

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Students & Residents

Valuable insights and advice for future neurologists.

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Case Reports