Dr. Elizabeth Leroux, McGill University, Highlights Key Articles in Headache Literature from 2022-2023
On the final day of the 2023 Scottsdale Headache Symposium, Dr. Elizabeth Leroux, Past President of the Canadian Headache Society, presented a review of the state of headache literature from 2022 through 2023. Dr. Leroux outlined key areas in scientific publications focusing on the following areas and included links to notable papers:
- What’s new in cluster headache treatments
- Use of psilocybin for treatment
- Occipital neuromodulation
- Deep brain stimulation
- An explosion of publications on calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) therapies
- Lampl C, MaassenVanDenBrink A, Deligianni CI, et al. The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis. J Headache Pain. 2023 May 19;24(1):56. doi: 10.1186/s10194-023-01594-1.
- Schoenen J, Van Dycke A, Versijpt J, Paemeleire K. Ten open questions in migraine prophylaxis with monoclonal antibodies blocking the calcitonin-gene related peptide pathway: a narrative review. J Headache Pain. 2023 Aug 1;24(1):99. doi: 10.1186/s10194-023-01637-7.
- New potential targets for therapies
- ATP-sensitive K+ channels (kATP)
- TRPA1 ion channel
- Updates on the glymphatic system
- The association between macromastia and headache
One publication applauded by Dr. Leroux focused on guidelines for the diagnosis and management of spontaneous intracranial hypotension:
- Cheema S, Anderson J, Angus-Leppan H, et al. Multidisciplinary consensus guideline for the diagnosis and management of spontaneous intracranial hypotension. Journal of Neurology, Neurosurgery & Psychiatry. 2023;94:835-843.
A notable systematic review and meta-analysis focused on new daily persistent headache:
- Cheema S, Mehta D, Ray JC, et al. New daily persistent headache: A systematic review and meta-analysis. Cephalalgia. 2023 May;43(5):3331024231168089. doi: 10.1177/03331024231168089.
Dr. Leroux, who is Founder and Chair of Migraine Canada, Headache Specialist at the Montreal Neurology Clinic, and Faculty Lecturer at McGill University, indicated that her list of topics and specific papers is highly subjective. Not all articles mentioned by Dr. Leroux have been included in this news brief.