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The investigational molecule BPN14770 (Tetra Discovery Partners, Grand Rapids, MI) is being studied as potential treatment for multiple cognitive disorders, including Fragile X syndrome, Alzheimer’s disease, and traumatic brain injury. A potentially neuroprotective molecule, BPN14770 is the first allosteric inhibitor of PDE4D and inhibits the active form of PDE4D preferentially. A role for PDE4D in learning, memory, and cognition is established across multiple species, from the dunce mutant fruit fly that is unable to learn conditioned behavior, to children with a rare cause of...
After 20 weeks of therapy with ampreloxetine (Theravance Biopharma, South San Francisco, CA) participants in a phase 2 clinical trial (NCT02705755) had sustained improvements in symptoms from neurogenic orthostatic hypotension (nOH). In the phase 2 study, participants with nOH who completed a single ascending dose study (1-20 mg/day) were treated with ampreloxetine (5, 10, or 20 mg/day) on an open-label basis. After 4 weeks of treatment, 16 participants had a mean reduction in symptom severity of 2.4 points on the Orthostatic Hypotension Symptom Assessment (OHSA) Question #1 that measures...
The Drug Enforcement Agency DEA has designated solriamfetol (Sunosi; Jazz Pharmaceuticals, Philadelphia, PA) a schedule IV agent, meaning that it has low potential for abuse or dependence. Solriamfetol was approved for treatment of excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea (OSA) in March, 2017 and pooled efficacy and safety data were recently presented at SLEEP2019 as reported by Practical Neurology previously. "Jazz Pharmaceuticals focuses on doing what is best for patients and we are committed to the safe and appropriate use of our medicines...
Janel Schneider, MD
Peter McAllister, MD
Emer R. McGrath, MB, PhD