Showing 971-980 of 1059 results for "".
- FDA Accepts Priority Review Application for Fenfluramine for Lennox-Gastaut Seizureshttps://practicalneurology.com/news/fda-accepts-priority-review-application-for-fenfluramine-for-lennox-gastaut-seizures/2469762/The Food and Drug Administration (FDA) has accepted for filing and granted priority review to a supplemental New Drug Application (sNDA) for the use of fenfluramine (Fintepla; Zogenix, Emeryville, CA) for seizures associated with Lennox-Gastaut syndrome (LGS). The FDA granted priority review with
- National Treatment and Diagnostic Alzheimer Disease Registry Announcedhttps://practicalneurology.com/news/national-treatment-and-diagnostic-alzheimer-disease-registry-announced/2469739/Launch of a new national registry to collect real-world evidence on the diagnosis, treatment, and outcomes in Alzheimer disease (AD) has been announce. The registry is a joint initiative of The Alzheimer’s Association; the American College of Radiology; the American Society of Neuroradiolog
- Retrospective Study Shows Ischemic Stroke and Atrial Fibrillation Linked in Timehttps://practicalneurology.com/news/retrospective-study-shows-ischemic-stroke-and-atrial-fibrillation-linked-in-time/2469709/As published in JAMA Cardiology, data from continuous rhythm monitoring devices showed atrial fibrillation (AF) was directly and transiently associated in time with ischemic strokes. Among 891 people who had an ischemic stroke during continuous cardiac monitoring, 76.5% had no
- Fenfluramine Indication Expansion to Include Lennox-Gastaut Syndrome Submitted to FDAhttps://practicalneurology.com/news/fenfluramine-indication-expansion-to-include-lennox-gastaut-syndrome-submitted-to-fda/2469704/A supplemental new drug application (sNDA) has been submitted to the Food and Drug Administration (FDA) for fenfluramine (Fintepla; Zogenix, Emeryville, CA) to treat seizures associated with Lennox-Gastaut Syndrome (LGS). In a randomized controlled phase 3 clinical trial (
- Lecanemab, an Antibody to Amyloid Beta, Reduced Amyloid Levels and Cognitive Declinehttps://practicalneurology.com/news/lecanemab-an-antibody-to-amyloid-beta-reduced-amyloid-levels-and-cognitive-decline/2469653/Preliminary assessment of results clinical trials of lecanemab (BAN2401; Biogen, Cambridge, MA; Eisai, Tokyo, Japan) for potential treatment of Alzheimer disease (AD), were presented at the Alzheimer’s Association International Conference July 26-30, 2021. Lecanemab reduced brain
- Cases of Dementia Projected to Increase Worldwidehttps://practicalneurology.com/news/cases-of-dementia-projected-to-increase-worldwide/2469646/Data presented at the Alzheimer's Association International Congress July 26-30, 2021 show that all types of dementia have been on the rise in recent years and are predicted to increase further. Rates of early-onset dementia are also increasing, and in the US, mortality from Alzheimer diseae
- Wrist-Worn Neuromodulation Device Cost Effective for Essential Tremorhttps://practicalneurology.com/news/wrist-worn-neuromodulation-device-cost-effective-for-essential-tremor/2469601/According to data from a retrospective analysis, the wrist-worn neuromodulation device (Cala Trio; Cala Health, Inc, Burlingame, CA) is a cost-saving treatment option for individuals with essential tremor (ET). The analysis demonstrates that ET is associated with substantial health care resource
- Neurofilament Light Levels Correlate With Cognitive Declinehttps://practicalneurology.com/news/neurofilament-light-levels-correlate-with-cognitive-decline/2469564/In a study comparing potential biomarkers for cognitive decline in Alzheimer disease, neurofilament light (NfL) levels correlated more strongly with cognitive decline compared with total tau (T-tau) levels. Baseline plasma NfL also associated with neuroimaging biomarkers cortical thickness, hippo
- Half of Children with Inflammatory Syndrome After COVID-19 Have Neurologic Symptomshttps://practicalneurology.com/news/half-of-children-with-inflammatory-syndrome-after-covid-19-have-neurologic-symptoms/2469560/Approximately half of children with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) present with new neurologic symptoms involving the central and peripheral nervous systems, in the absence of respiratory symptoms. Neurologic symptoms were seen more fre
- Proteins Linked to Epilepsy May Lead to new Drug Targetshttps://practicalneurology.com/news/proteins-linked-to-epilepsy-may-lead-to-new-drug-targets/2469524/In a study of adult brain tissue over 900 proteins were found associated with epilepsy. The study showed altered levels of brain proteins predominated in the hippocampus. In the brain tissue samples examined, 134 proteins were significantly changed in both the hippocampus and frontal cortex