Showing 1581-1590 of 1697 results for "".
- Gantenerumab Did Not Slow Cognitive Decline in People with Early Alzheimer Disease According to 2 Clinical Trial Resultshttps://practicalneurology.com/news/ganenterumab-did-not-slow-cognitive-decline-in-people-with-early-alzheimer-disease-according-to-2-clinical-trial-results/2470338/Treatment with the monoclonal antibody (mAb) gantenerumab (Genentech, South San Francisco, CA; Roche, Basel, Switzerland) was associated with a lower amyloid plaque burden in people with early Alzheimer disease (AD), but it did not slow cognitive decline after 116 weeks. These findings are from t
- FDA Fast Track Designation and IND Clearance Granted to Novel Gene Therapy for GRN-Related Frontotemporal Dementiahttps://practicalneurology.com/news/fda-fast-track-designation-and-ind-clearance-granted-to-novel-gene-therapy-for-grn-related-frontotemporal-dementia/2470333/The Food and Drug Administration (FDA) cleared the investigational new drug (IND) application for AVB-101 (AviadoBio; London, United Kingdom), an adeno-associated virus (AAV) gene therapy developed as a potential treatment for people with frontotemporal dementia (FTD) with mutations in the progra
- Encouraging Safety Data for Investigational NTRX-07 Therapy for Alzheimer Disease Targeting Cannabinoid Type 2 Receptorhttps://practicalneurology.com/news/encouraging-safety-data-for-investigational-ntrx-07-therapy-for-alzheimer-disease-targeting-cannabinoid-type-2-receptor/2470329/In a phase 1b clinical trial, short-term treatment with NTRX-07 (NeuroTherapia, Cleveland, Ohio), an investigational small molecule targeting the cannabinoid type 2 (CB2) receptor, was associated with favorable pharmacokinetic and safety data in a small group of healthy volunteers and a subset of
- Study from CTAD 2023 Compares Sensitivity of 4 Blood-Based Biomarkers for Preclinical Alzheimer Diseasehttps://practicalneurology.com/news/study-from-ctad-2023-compares-sensitivity-of-4-blood-based-biomarkers-for-preclinical-alzheimer-disease/2470323/A study comparing the sensitivity of amyloid beta (Aβ) 40/42 ratio, plasma phosphorylated tau at threonine 181 (p-tau181), p-tau217, and neurofilament light chain (NfL) in low-risk (LR) versus high-risk (HR) cognitively healthy adults found that p-tau217 was associated with both high-risk fo
- Labcorp Launches New Amyloid-Tau-Neurodegeneration Biomarker Blood Testhttps://practicalneurology.com/news/labcorp-launches-new-amyloid-tau-neurodegeneration-biomarker-blood-test/2470308/Labcorp has announced that its ATN Profile (Laboratory Corporation of America Holdings, Burlington, NC) test for identifying and assessing biological changes in blood biomarkers associated with Alzheimer disease (AD) has launched and is available in the United States. Physicians can use the tests
- Favorable Skin Tolerability and Adhesion Results Found in Study of Adlarity Transdermal Patcheshttps://practicalneurology.com/news/favorable-skin-tolerability-and-adhesion-results-found-in-study-of-adlarity-transdermal-patches/2470298/Results of a study published online in Alzheimer Disease & Associated Disorders revealed favorable outcomes in terms of skin tolerability and adhesion for Adlarity (donepezil transdermal system; Corium, Boston, MA) compared with placebo. The Food and Drug Administration (FDA) approve
- Stroke Risk Increases Significantly After Head Injury, 30-Year Study Findshttps://practicalneurology.com/news/stroke-risk-increases-significantly-after-head-injury-30-year-study-finds/2470292/People who have experienced traumatic brain injury (TBI), regardless of severity, are at significantly greater risk of ischemic stroke, according to a study presented at the 148th Annual Meeting of the American Neurological Association. The study also found that the risk of ischemic stroke increa
- Probiotics May Have Beneficial Effects in Patients with Parkinson Diseasehttps://practicalneurology.com/news/probiotics-may-have-beneficial-effects-in-patients-with-parkinson-disease/2470277/Probiotic use may be associated with improved Parkinson disease (PD) symptoms, according to studies presented at the 2023 International Congress of Parkinson’s Disease and Movement Disorders. Results from one study suggest that prolonged probiotic use may have potential as a therapy for pat
- Study Finds Evidence of Link Between Absence Seizures and Myelin Plasticityhttps://practicalneurology.com/news/study-finds-evidence-of-link-between-absence-seizures-and-myelin-plasticity/2470079/Results from a novel study presented at the American Epilepsy Society Annual Meeting revealed an association between seizures and myelin plasticity, opening exciting possibilities for future research. Researchers documented an increase in both the total number of myelinated fibers as well as thic
- MRI Reveals Enlarged Perivascular Spaces in Individuals With Migrainehttps://practicalneurology.com/news/mri-reveals-enlarged-perivascular-spaces-in-individuals-with-migraine/2470074/A new study presented at the annual meeting of the Radiological Society of North America (RSNA) was the first to report evidence of enlarged perivascular spaces in study participants with migraine. Researchers also documented an association between the number of enlarged perivascular spaces found