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Case Report: Hemiparkinsonism in a Patient With Multiple Sclerosis image

Case Report

Case Report: Hemiparkinsonism in a Patient With Multiple Sclerosis

In this case, there was a causal relationship between comorbid diseases.

Andrea P. Lee, MD; Giulietta M. Riboldi, MD; Ilya Kister, MD; Jonathan E. Howard, MD; and Ritesh A. Ramdhani, MD

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Cover Focus: Multiple Sclerosis & Demyelinating Disorders

Multiple Sclerosis Misdiagnosis

Accurate diagnosis requires correspondence to typical clinical syndromes, correct interpretation of radiologic and CSF data, and thorough evaluation for mimics.

Alexandra Galati, MD; and Marwa Kaisey, MD

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POINT-COUNTERPOINT: Natalizumab Extended-Interval Dosing

Optimism vs caution for using extended-interval dosing to prevent progressive multifocal leukoencephalopathy.

David B. Clifford, MD; and John F. Foley, MD

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Emerging Therapies for Progressive Multiple Sclerosis

A number of agents with putative neuroprotective effects have shown promise in recent clinical trials.

Matthew Tremblay, MD, PhD

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Immunopathogenesis of Multiple Sclerosis

Disruption of immune tolerance, inflammation, and blood-brain–barrier breach lead to demyelination and axonal injury.

Neeta Garg, MD; Ye Hu, MD; and Kottil W. Rammohan, MD

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Pediatric-Onset Multiple Sclerosis

Information from clinical trials in children with MS is furthering understanding and improving treatment options for this rare presentation.

Brenda L. Banwell, MD; and Duriel I. Hardy, MD

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Neuromyelitis Optica Spectrum Disorders

It is critical to maintain a high index of suspicion for these conditions when evaluating a patient with demyelination to avoid delays in treatment.

Michael J. Bradshaw, MD; and Dorlan Kimbrough, MD

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Guest Medical Editor's Page

A Coming of Age for Neuroimmunology

Increasingly complex diagnostics and highly effective disease-modifying therapy come with challenges in clinical decision making.

Aaron M. Carlson, MD

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Neurosyphilis-Induced Psychosis

The return of the great imitator makes it critical to know the guidelines for testing for neurosyphilis.

Nabil Ali, MD; and Veronica Hocker, MD

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Spotlight Topic: Neuropsychiatry

Cognitive Complaints and Neuropsychologic Testing

When should neuropsychologic tests be ordered and what questions should testing answer?

Nabil Ali, MD; Laura M. Clark, PhD, ABPP; and Kendra Corning, PsyD, HSPP

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MS Minute: Late-Breaking Data From ECTRIMS—Evobrutinib Safety and Efficacy

A potential new first-in-class treatment affects Bruton's tyrosine kinase.

Daniel Kantor, MD, FAAN, FANA

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Healthy Cognitive Aging

There are evidence-based tools for staying sharp throughout the lifespan.

Brian K. Lebowitz, PhD, ABPP-CN; Elizabeth Londen, PhD; and Thomas Preston, PhD, ABPP-CN

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Cover Focus: Technology & Wellness

Treating Stress to Improve Neurologic Outcomes

Research on the interaction between hormones and seizures supports the importance of helping patients manage stress.

Riley Bove, MD, MMSc; and Graham R. Huesmann, MD, PhD

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Guest Medical Editor's Page

Wellness and Neurology

There is clear evidence for promoting wellness practices to all patients with neurologic disorders.

Patricia K. Coyle, MD, FAAN, FANA

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Seeking Breakthroughs: The Physician Perspective

A roundtable discussion with Claudia A. Chiriboga, MD, MPH; Jeffrey L. Cummings, MD, ScD; and Nir Lipsman, MD, PhD

Claudia A. Chiriboga, MD, MPH; Jeffrey L. Cummings, MD, ScD; and Nir Lipsman, MD, PhD

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Seeking Breakthroughs: The Startup Perspective

A roundtable discussion with Chase Spurlock, PhD, IQuity; Michal Izrael, PhD, Kadimastem Ltd; Kevin Hrusovsky, Quanterix; and J. Michael Ryan, MD, Rodin Therapeutics

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Biomarkers in Multiple Sclerosis

Biomarkers have resulted from breakthrough treatments and, in turn, provide targets for more breakthroughs.

Neeta Garg, MD; Ye Hu, MD; and Kottil W. Rammohan, MD

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Neurologists Wanted!

A recently graduated resident and new professor recommends ways to attract medical students to the specialty of neurology.

Rachel Gottlieb-Smith, MD

Vasculitis Presenting as a Hypertensive Crisis With Back Pain image

Case Report

Vasculitis Presenting as a Hypertensive Crisis With Back Pain

Because laboratory and imaging studies may not be sensitive enough to detect central nervous system vasculitis, maintain a low threshold for further evaluation when clinical suspicion is high.

Julia Blanter, MD; Michael Colin, MD; Asaff Harel, MD, MSc; Peter Sayegh, MD; Elizabeth Sharp, MD; and Jared Steinklein MD

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Seeking Breakthrough Treatments

Seeking Breakthroughs: The Industry Perspective

A roundtable discussion with Gregory Went, PhD, Adamas Pharmaceuticals; Lynn Kramer, MD, Eisai; Paulo Fontoura, MD, PhD, Genentech/Roche; Justin Gover, BSc, MBA, GW Pharmaceuticals; Marc Kamin, MD, SK Life Sciences; and Mike Davis, BSc, MBA, UCB

This Month's Issue
Case Report: Delayed Subdural Hematoma

Elaine Williams, MS, MD; Robert Glatter, MD; Steven Mandel, MD; and Jared Steinklein, MD

Genetic Mechanisms of Epilepsy

Elina Nikkola, PhD; and Vishal Shah, MD

Telemedicine & Epilepsy

Melissa Reider-Demer, DNP, MN, CNP; and Vishal Shah, MD