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MS Minute: Ibudilast image

Columns

MS Minute: Ibudilast

Ibudilast is a phosphodiesterase inhibitor that has shown some benefit for progressive multiple sclerosis in a phase 2 trial.

Abdul R. Alchaki, MD; and Andrew D. Goodman, MD

Susac Syndrome image

Cover Focus

Susac Syndrome

A triad of encephalopathy, branch retinal artery occlusions, and sensorineural hearing loss.

Ilka Kleffner, MD; Catharina C. Gross, PhD; Marius Ringelstein, MD; Jörg Rehrmann, MD; Markus Kraemer, MD; and Jan Dörr, MD

2019 Drug and Device Approvals in Neurology image

Special Report

2019 Drug and Device Approvals in Neurology

Challenge Case Report: Aseptic Meningitis Worsening With Treatment image

Case Reports

Challenge Case Report: Aseptic Meningitis Worsening With Treatment

Diagnosis should be re-evaluated when clinical situations change.

David Horvat, MD; Jack Lovell, DO; and Glen Cook Jr, MD

Case Report: Seizure, Fever, Hallucinations, & Vision Loss image

Case Reports

Case Report: Seizure, Fever, Hallucinations, & Vision Loss

A circuitous route to dual diagnoses.

Elizabeth Carroll, MD; Asya I. Wallach, MD; Arielle Kurzweil, MD; Steven Frucht, MD; Thomas Berk, MD; Michael Boffa, MD; and Ilya Kister, MD

MS Minute: Oral Therapies for MS image

Columns

MS Minute: Oral Therapies for MS

The advent of oral therapies has ushered in a new phase of disease-modifying treatments.

Neeta Garg, MD; Micheline McCarthy, MD, PhD; and Ameeta Karmarkar, MD

Case Report: Hemiparkinsonism in a Patient With Multiple Sclerosis image

Case Report

Case Report: Hemiparkinsonism in a Patient With Multiple Sclerosis

In this case, there was a causal relationship between comorbid diseases.

Andrea P. Lee, MD; Giulietta M. Riboldi, MD; Ilya Kister, MD; Jonathan E. Howard, MD; and Ritesh A. Ramdhani, MD

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Cover Focus: Multiple Sclerosis & Demyelinating Disorders

Multiple Sclerosis Misdiagnosis

Accurate diagnosis requires correspondence to typical clinical syndromes, correct interpretation of radiologic and CSF data, and thorough evaluation for mimics.

Alexandra Galati, MD; and Marwa Kaisey, MD

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POINT-COUNTERPOINT: Natalizumab Extended-Interval Dosing

Optimism vs caution for using extended-interval dosing to prevent progressive multifocal leukoencephalopathy.

David B. Clifford, MD; and John F. Foley, MD

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Emerging Therapies for Progressive Multiple Sclerosis

A number of agents with putative neuroprotective effects have shown promise in recent clinical trials.

Matthew Tremblay, MD, PhD

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Immunopathogenesis of Multiple Sclerosis

Disruption of immune tolerance, inflammation, and blood-brain–barrier breach lead to demyelination and axonal injury.

Neeta Garg, MD; Ye Hu, MD; and Kottil W. Rammohan, MD

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Pediatric-Onset Multiple Sclerosis

Information from clinical trials in children with MS is furthering understanding and improving treatment options for this rare presentation.

Brenda L. Banwell, MD; and Duriel I. Hardy, MD

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Neuromyelitis Optica Spectrum Disorders

It is critical to maintain a high index of suspicion for these conditions when evaluating a patient with demyelination to avoid delays in treatment.

Michael J. Bradshaw, MD; and Dorlan Kimbrough, MD

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Guest Medical Editor's Page

A Coming of Age for Neuroimmunology

Increasingly complex diagnostics and highly effective disease-modifying therapy come with challenges in clinical decision making.

Aaron M. Carlson, MD

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Spotlight Topic: Neuropsychiatry

Cognitive Complaints and Neuropsychologic Testing

When should neuropsychologic tests be ordered and what questions should testing answer?

Nabil Ali, MD; Laura M. Clark, PhD, ABPP; and Kendra Corning, PsyD, HSPP

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Neurosyphilis-Induced Psychosis

The return of the great imitator makes it critical to know the guidelines for testing for neurosyphilis.

Nabil Ali, MD; and Veronica Hocker, MD

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Cover Focus: Technology & Wellness

Treating Stress to Improve Neurologic Outcomes

Research on the interaction between hormones and seizures supports the importance of helping patients manage stress.

Riley Bove, MD, MMSc; and Graham R. Huesmann, MD, PhD

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MS Minute: Late-Breaking Data From ECTRIMS—Evobrutinib Safety and Efficacy

A potential new first-in-class treatment affects Bruton's tyrosine kinase.

Daniel Kantor, MD, FAAN, FANA

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Healthy Cognitive Aging

There are evidence-based tools for staying sharp throughout the lifespan.

Brian K. Lebowitz, PhD, ABPP-CN; Elizabeth Londen, PhD; and Thomas Preston, PhD, ABPP-CN

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Guest Medical Editor's Page

Wellness and Neurology

There is clear evidence for promoting wellness practices to all patients with neurologic disorders.

Patricia K. Coyle, MD, FAAN, FANA

This Month's Issue
Special Report: Neuro-oncology

Shruti Bhandari, MD; Rohit Kumar, MD; Megan Nelson, MD; Donald Miller, MD; and Brian J. Williams, MD

Takayasu Disease and Stroke

Harold P. Adams Jr., MD