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Early Clinically Unsuspected
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Case Report

Early Clinically Unsuspected Alzheimer’s Disease

Biomarkers can be important tools for diagnosis.

Georgette A. Khoury, MSN, APRN-BC; and Ira J. Goodman, MD

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About the Cover Artist

Alzheimer’s Disease Drug Development &
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Alzheimer’s Disease Drug Development & Emerging Therapies

We must all work together to accelerate clinical trials and create meaningful new therapies for Alzheimer’s disease.

Jeffrey L. Cummings, MD, ScD; and Kate Zhong, MD

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Brain Health & Dementia Risk Reduction

As preventative neurology becomes possible, it is worth providing risk reduction care to those at risk of Alzheimer’s disease dementia.

Nabeel Saif BA, MS; George Sadek, BA; Sonia Bellara, MBBS; Hollie Hristov, FNP; and Richard S. Isaacson, MD

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Sleep Disorders & Dementia

Sleep disorders are emerging as a biomarker for prodromal dementia.

Winnie Pao, MD

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Neuropsychiatric Aspects of Alzheimer’s Disease

Clinically significant neuropsychiatric symptoms need evidence-based treatment.

Zahra Goodarzi, BHSc (Hon), MD, MSc, FRCPC; and Zahinoor Ismail, MD, FRCPC

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Frontotemporal Dementias

Careful clinical, neuropsychologic, and imaging investigations make differential diagnosis of variants possible.

Ryan Taylor, MD; and Elizabeth Finger, MD

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Lewy Body Dementia

The second highest cause of dementia is highly variable.

James E. Galvin, MD, MPH

Disclosing Risk Factors to Individuals Without
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Disclosing Risk Factors to Individuals Without Cognitive Impairment

Negative consequences of risk factor disclosure are likely to be most severe among people who are inadequately prepared to receive the information.

Joshua D. Grill, PhD

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Alzheimer’s Disease Biomarkers

Amyloid, tau, neurodegeneration (ATN)—where do we go from here?

Serge Gauthier, CM, CQ, MD, FRCPC; and Pedro Rosa-Neto, MD, PhD

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Brain Imaging in Differential Diagnosis of Dementia

Imaging biomarkers hold the promise of earlier diagnosis that may lead to more effective treatment.

Mathew R. Ayers, DO; Diana Svaldi, PhD; and Liana G. Apostolova, MD, MS

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Neuropsychologic Assessment for Neurodegeneration

What is the value of neuropsychologic assessment in neurodegenerative diseases?

Jennifer Medina, PhD; and Sarah J. Banks, PhD, ABPP-CN

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Preclinical, Prodromal, and Dementia Stages of Alzheimer’s Disease

Identifying the correct stage of Alzheimer’s disease helps in managing risk, diagnosis, and management decisions.

Douglas W. Scharre, MD

Alzheimer’s and Other Dementias—From Translation
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Alzheimer’s and Other Dementias—From Translation to Transformation

Progress in understanding dementia will take us from translation to transformation.

Jeffrey L. Cummings, MD, ScD

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Columns

Dementia Insights: Cognitive Consequences of Perimenopause

A possible contribution of perimenopause should be considered when evaluating women with cognitive complaints.

Ronald Devere, MD, FAAN

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Sleep & Neurodegenerative Disease

Sleep problems are common and treatable in neurodegenerative disorders, and may also be a treatable risk factor and early biomarker.

Raman K. Malhotra, MD

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Sleep, Sleeplessness, & Neuropsychiatric Conditions

Sleep disturbances are symptoms of psychiatric conditions that can worsen prognosis; however, nonpharmacologic treatments are available and effective.

Fiona Barwick, PhD

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Vascular Cognitive Impairment

Targeting risk factors may decrease vascular cognitive impairments.

Saud Alhusaini, MD, PhD; and Eric E. Smith, MD, MPH

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Dementia Insights: Blood Pressure Control and Cognitive Impairment

Could recommendations for more aggressive blood pressure control worsen prognosis for vascular and neurodegenerative cognitive impairments?

Ronald Devere, MD, FAAN

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Spotlight Topic: Neuropsychiatry

Cognitive Complaints and Neuropsychologic Testing

When should neuropsychologic tests be ordered and what questions should testing answer?

Nabil Ali, MD; Laura M. Clark, PhD, ABPP; and Kendra Corning, PsyD, HSPP