Pimavanserin Reduce Risks of Dementia-Related Psychotic Relapse Almost Threefold
In top-line results from the pivotal phase 3 HARMONY (NCT03325556) study, treatment with pimavanserin vs placebo (Nuplazid, Acadia Pharmaceuticals, San Diego, CA) reduced risk of psychotic relapse by 2.8 fold (HR = 0.353; one-sided P = .0023) for people with dementia-related psychosis (DRP). People treated with pimavanserin were 2.2 times less likely to discontinue the study medication compared with those treated with placebo (HR = 0.452; one-sided P= .0024). This finding met the predetermined primary endpoint; as a result, the study was terminated early for efficacy.
In an initial...