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A phase 2 proof-of-concept study will begin in the US later this year for LT3001 (Lumosa Therapeutics, Taipei, Taiwan), a novel therapy for treating acute ischemic stroke (AIS). Enrollment of participants for the phase 2 study in Taiwan will begin in 2020. Full enrollment is expected to take 2 years to complete; time to completion will depend upon outcomes observed. In animal studies, LT3001 restored cerebral blood flow and reduced ischemic/reperfusion injury. In phase 1 single-dose escalation studies, LT3001 was well tolerated with no adverse effects in16 healthy people. Those individuals...
LiveWell Dementia Specialists in Plantsville, CT has received $250,000 in funding for a 2-year project to engage people with dementia as research partners. The first of its kind, the Empowering Partnerships project aims to enhance research by developing a network of people with dementia, family care partners, and researchers to be involved in all aspects of clinical research. Inspired by a key recommendation from the 2017 National Research Summit on Dementia, this project aims to meet the request to fund more research on how people living with dementia and their care partners can...
Solriamfetol (Sunosi; Jazz Pharmaceuticals, Philadelphia, PA) has been approved by the Food and Drug Administration for the treatment of excessive daytime sleepiness in people with narcolepsy or obstructive sleep apnea (OSA) and is pending a scheduling decision from the Drug Enforcement Agency (DEA) in mid 2019. In pooled analysis of data from the TONES 2 and TONES 3 clinical trials (NCT01681121, NCT02348593, NCT02348606), the efficacy and safety of solriamfetol was consistent (Table). After 12 weeks of treatment, the percentage of participants reported as having improvement on...
Emer R. McGrath, MB, PhD
Nabeel Saif BA, MS; George Sadek, BA; Sonia Bellara, MBBS; Hollie Hristov, FNP; and Richard S. Isaacson, MD
Jeffrey L. Cummings, MD, ScD