Ketogenic Diet May Reduce Disability and Improve Quality of Life in Multiple Sclerosis

A preliminary study found that a ketogenic diet may be safe for people with multiple sclerosis (MS) and reduce fatigue, depression, and disability. Improved quality of life may also occur with a ketogenic diet for people with MS. 

During the study, 83% of participants adhered to a ketogenic diet; adherence was monitored with daily urine ketone testing. Participants completed surveys regarding their mental and physical health with a range of 100 points. Over a 6-month period, physical health improved from 67 to 79 and mental health improved from 71 to 82. 

On the timed 6-minute walk test, distances completed improved 1,631 feet at the start of the study to 1,733 feet.

“Our study provides evidence that a ketogenic diet may indeed be safe and beneficial, reducing some symptoms for people with MS, when used over a 6-month period,” said J. Nicholas Brenton, MD, University of Virginia, Charlottesville. “However, more research is needed because there are potential risks associated with ketogenic diets, such as kidney stones, digestive issues, and nutrient deficiencies. It is important that people with MS consult with their doctor before making any big changes to their diet, and that they be regularly monitored by a physician and registered dietitian while on a ketogenic diet.”

For this study, 65 people with relapsing-remitting MS consumed a ketogenic diet for 6 months that included 2 to 3 ketogenic meals daily. The diet consisted of 1 to 2 servings of low-carbohydrate proteins such as eggs, fish, or meat; 2 to 4 tablespoons of fat, such as butter, oil, avocado, ghee, or heavy cream; and 1 to 2 cups of nonstarchy vegetables such as cucumbers, leafy greens, or cauliflower. Dietary adherence was monitored with daily urine ketone testing. 

The study results will be presented at the American Academy of Neurology 74th Annual Meeting, held in person in Seattle, April 2 to 7, 2022 and virtually, April 24 to 26, 2022.