Brain-Computer Interface, Implanted Endovascularly, Allows People With Paralysis to Operate Computers With Their Thoughts

In a first-in-human study, 4 participants were implanted with a brain-computer interface (BCI) (Stentrode, Synchron, Brooklyn, NY) delivered via an endovascular stent to the superior sagittal sinus. The brain-computer interface allowed participants with paralysis to independently perform computer-based daily tasks (eg, online banking, sending e-mails, or online shopping).

Via the BCI, the brain sends signals from the motor cortex to a computer through an electronics unit implanted in a subcutaneous pocket. These delivery modes for the BCI prevent the need for craniotomy or neurosurgery. In this study, 3 individuals used the device with eye movement tracking to operate a computer. From that experience, an algorithm was built that allowed the 4th participant to move cursors with their thoughts. 

The study enrolled 5 participants with amyotrophic lateral sclerosis (ALS), however only 4 proceeded with the implant due to suitable anatomy. An endovascular catheter was used to insert the implant and all 4 participants successfully completed 12-month follow-up with no serious adverse events (eg, no clots, no bleeds, and no infections). Post-operative imaging of all participants demonstrated patent blood vessels and no migration of the BCI. 

These data are being presented at the American Academy of Neurology Annual Meeting April 1-7, in Seattle, WA.