A sagittal 3T FLAIR* brain MRI shows multiple lesions with the central vein sign (orange arrows), appearing as hypointense dots or lines, located centrally within the lesion, depending on the blood vessel orientation. The FLAIR* technique was developed by Daniel S. Reich, MD, PhD and colleagues as described in Sati P, et al. Radiology. 2012;265(3):926-932. Image contributed by Daniel S. Reich, MD, PhD.