Study: Women and Men with APOE Epsilon 4 Gene at Equal Risk for Alzheimer’s Disease


Although women with the APOE e3/e4 genotype have been thought to be at greater risk for Alzheimer’s disease, new research suggests that men and women between 55 and 85 years of age with the genotype have nearly the same odds of developing the disease. Reviewing data on nearly 58,000 participants from the Global Alzheimer’s Association Interactive Network, researchers sought to determine the extent to which sex and APOE genotype affect the risks for developing MCI and AD (JAMA Neurol. Published online August 28, 2017). They found that men and women with the APOE e3/e4 genotype from ages 55 to 85 years did not show a difference in AD risk. However, women had an increased risk compared with men between the ages of 65 and 75 years. Men with APOE e3/e4 had an increased risk of AD compared with men with APOE e3/e3. The APOE e2/e3 genotype conferred a protective effect on women decreasing their risk of AD more than men. 


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