Alzheimer’s & Dementia

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Level of Education Shown Not to Correlate to Rate of Cognitive Decline in Those With or Without Dementia

Thursday, February 07, 2019—Some studies have suggested that a higher level of education may correlate with lower incidence of dementia, which has been interpreted as suggesting education could increase …

Tau Pathology of Alzheimer’s Linked to Sleep-Wake Cycle

Wednesday, February 06, 2019—Poor sleep is a symptom of Alzheimer’s disease (AD) that worsens as the disease progresses and is also suggested to be an early symptom of AD. It has been known for some…

Genentech Discontinuing Phase 3 Clinical Studies of Crenezumab for Early Alzheimer’s Disease

Thursday, January 31, 2019—The phase 3 studies, CREAD 1 (NCT02670083) and CREAD 2 (NCT03114657), of crenezumab (Genetech, South San Francisco, CA), an investigational monoclonal antibody to am…

FDA Grants Breakthrough Device Designation for Alzheimer’s Disease Screening Test

Wednesday, January 30, 2019—The Food and Drug Administration (FDA) has granted Breakthrough Device Designation for a brain amyloidosis blood test (C2N Diagnostics, St. Louis, MO) that screens patien…

Leaky Blood-Brain Barrier May Be Early Biomarker for Cognitive Dysfunction

Monday, January 21, 2019—In a study published in the journal Nature Medicine, researchers showed a correlation between damage of capillaries in the hippocampal region and early cognitive dys…

First Patient Enrolled in Phase 3 Trial of Low-Dose Formulation of Levetiracetam for Mild Cognitive Impairment

Thursday, January 17, 2019—A first patient has been enrolled in a phase 3 clinical trial of a proprietary low-dose formulation of the antiepileptic drug levetiracetam (AGB101; AgeneBio, Baltimore,MD) fo…

Breakthrough Device Designation Granted to Brain-Monitoring Technology

Wednesday, January 09, 2019—The Food and Drug Administration has granted breakthrough device designation to a brain health monitoring technology (Neurametrix; San Francisco, CA). The approved use is moni…

American Academy of Neurology Call for Uniformity in Brain Death Standards

Thursday, January 03, 2019—Noting that only 1 state, Nevada, has adopted legislation requiring use of medically accepted guidelines for determining brain death, the American Academy of Neurology (AAN) i…


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Launched in 2002, Practical Neurology is a publication uniquely dedicated to presenting current approaches to patient management, synthesis of emerging research and data, and analysis of industry news with a goal to facilitate practical application and improved clinical practice for all neurologists. Our straightforward articles give neurologists tools they can immediately put into practice.