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Individuals with mild cognitive impairment (MCI) who received a structured behavioral intervention in a randomized clinical trial (NCT02926157) designed to reset their circadian rhythms had improved sleep quality compared to those who did not receive the intervention. The chronotherapy intervention included sleep hygiene education, bright light therapy, physical activity phone counseling, and physical activity tracking. Participants who received the intervention had significantly improved objectively measured sleep efficiency (P =.03), sleep fragmentation (P = .02), wake after sleep...
College athletes with attention deficit hyperactivity disorder (ADHD) may have more severe symptoms and take longer to recover from concussion. Athletes with ADHD taking psychostimulant medication for ADHD (n = 20) and those who were not taking medication (n = 20) took 12 and 10 days, respectively, to recover from concussions. This was significantly longer than the 4 days to recovery experienced by those without ADHD (n = 80). The study used data from the NCAA-Department of Defense Grand Alliance: Concussion Assessment, Research, and Education (CARE) Consortium. All the athletes were...
Over a 48-week period, treatment with traneurocin (NA-831; Neuroactiva, San Jose, CA) improved cognition and global functioning in people with mild cognitive impairment (MCI). Traneurocin is an endogenous small molecule that was well-tolerated with no adverse events. Individuals with MCI or early onset Alzheimer’s disease (EOAD) treated with traneurocin (10 mg for those with MCI; 30 mg for those with EOAD) had improved cognition after 12 weeks of treatment compared with those given placebo (P < .001). Cognition was measured with the brief cognitive rating scale (BRCS) and the...
Jennifer Medina, PhD; and Sarah J. Banks, PhD, ABPP-CN
Janel Schneider, MD
Nabeel Saif BA, MS; George Sadek, BA; Sonia Bellara, MBBS; Hollie Hristov, FNP; and Richard S. Isaacson, MD