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Solriamfetol (Sunosi; Jazz Pharmaceuticals, Philadelphia, PA) has been approved by the Food and Drug Administration for the treatment of excessive daytime sleepiness in people with narcolepsy or obstructive sleep apnea (OSA) and is pending a scheduling decision from the Drug Enforcement Agency (DEA) in mid 2019. In pooled analysis of data from the TONES 2 and TONES 3 clinical trials (NCT01681121, NCT02348593, NCT02348606), the efficacy and safety of solriamfetol was consistent (Table). After 12 weeks of treatment, the percentage of participants reported as having improvement on...
Each standard deviation increase in the apnea-hypoxia index (AHI) was associated with a 215-day (7 months) acceleration of epigenetic aging. Similarly, each standard deviation increase in the arousal index was associated with a 321-day acceleration in epigenetic aging. Epigenetic age acceleration was measured with DNA methylation-based markers. These associations were stronger in the female participants compared with male participants. “People's biological age might not be the same as their chronological age,” said lead author Xiaoyu Li, ScD, a postdoctoral research fellow...
In pooled data analysis, participants treated with 5 or 10 mg of lemborexant (Eisai, Woodcliff Lake, NJ) had significantly decreased insomnia symptom severity compared with those treated with placebo. The severity of insomnia decreased to levels below the clinical threshold for insomnia in approximately one-third of individuals treated with lemborexant when assessed at 1 month of treatment. Decreases in insomnia severity in people treated with lemborexant were sustained over 6 months and were significantly larger in magnitude, compared with people treated with placebo. Treatment with...
Jeffrey L. Cummings, MD, ScD
Emer R. McGrath, MB, PhD
Nabeel Saif BA, MS; George Sadek, BA; Sonia Bellara, MBBS; Hollie Hristov, FNP; and Richard S. Isaacson, MD