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Post hoc analysis shows that participants who took 100 mg or 200 mg of lasmitidan had statistically significant increases in the rate of pain relief and freedom from the most bothersome symptom (MBS) (ie, nausea, photophobia, or phonophobia) (P < .001 starting as early as 30 minutes after administration. Participants who rated themselves as nonresponders, poor responders, or good responder to triptans did not have significant differences in their responses to 200 mg lasmiditan in any measure (freedom from pain at 2 hours, freedom from MBS, or pain relief). Participants who...
In a retrospective case-matched study from Taiwan published in Neurology, persons with bipolar disorder (BPD) were almost 7 times more likely to develop Parkinson’s disease (PD). Incidence of PD in people with BPD was 0.7% vs 0.1% for those without BPD (HR 6.95; 95% CI: 6.95-8.02). Onset of PD earlier in those with BPD (64 vs 73 years; P < .001). For those with BPD, the risk of PD increased with the number of hospitalizations for psychiatric symptoms. These findings suggest a diagnosis of BPD with other findings of PD risk factors (eg, positive dopamine transporter [DaT] scan...
Results from multiple trials of SMN1gene-replacement therapy (Zolgensma; Avexis, Bannockburn, IL) show promise for single-dose treatment of spinal muscular atrophy (SMA). In the STRIVE phase 3 study for treatment of spinal muscular atrophy, 22 infants under age 6 months, diagnosed genetically (biallelic SMN1 mutations/deletions, 2 SMN2 copies), were treated. Of the 15 babies treated more than 13.6 months or who discontinued the study before then, 13 (87%) survived without needing permanent ventilation, in contrast to the 25-50% survival rate for children with SMA when untreated....
Saif A. Bushnaq, MD; and Sunil A. Sheth, MD
Katharine Nicholson, MD
Bob Azelby, MBA