Diseases & Diagnoses
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Data presented at the Alzheimer’s Association International Conference in Los Angeles, July 14-18, 2019 show that people living with Alzheimer’s disease (AD) have epileptic seizures up to 6.5 times more often than those without AD. People with dementia are also at higher risk for recurring seizures and for having a first seizure at a younger age than people without dementia who have seizures and this risk increases with time since diagnosis of AD. In a study analyzing health records for more than 2.8 million individuals, age 60 or more, 2.8% had a dementia diagnosis and...
It is well known that changes in sleep occur with aging. It has also been reported that there are additional changes in sleep that occur specifically in people with Alzheimer’s disease (AD). In people with AD compared with age-matched people without cognitive impairments, there are differences in EEG patterns during sleep, less time in REM sleep, and more profound circadian rhythm abnormalities (delayed circadian phase and sleep instability are most common). Further, the EEG changes are affected by amyloid deposition in the brain. Sleep problems also affect the risk of...
Research reported at the Alzheimer’s Association International Conference (AAIC) in Los Angeles July 14-18, 2019 identifies a number of differences in risk for and progression of Alzheimer’s disease (AD) in women, including sex-specific genes, structural brain network differences, and different glucose metabolism during verbal memory tasks. Prevalence of AD is higher in women vs men (2:1), and although, it has long been thought that this is because of a longer life-span in women, this new evidence suggests other biologic mechanisms are involved. Rebecca M. Edelmeyer, MD,...
Peter McAllister, MD
Jeffrey L. Cummings, MD, ScD; and Kate Zhong, MD
Douglas W. Scharre, MD