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In a retrospective case-matched study from Taiwan published in Neurology, persons with bipolar disorder (BPD) were almost 7 times more likely to develop Parkinson’s disease (PD). Incidence of PD in people with BPD was 0.7% vs 0.1% for those without BPD (HR 6.95; 95% CI: 6.95-8.02). Onset of PD earlier in those with BPD (64 vs 73 years; P < .001). For those with BPD, the risk of PD increased with the number of hospitalizations for psychiatric symptoms. These findings suggest a diagnosis of BPD with other findings of PD risk factors (eg, positive dopamine transporter [DaT] scan...
In a double-blind phase 2 study (NCT02975349), adult participants with multiple sclerosis (MS) who were treated with evobrutinib (EMD-Serono, Rockland, MA) (75 mg taken orally once or twice daily) had reduced numbers of T1 gadolinium enhancing (Gd+) lesions as early as 12 weeks after initiating treatment (Table 1). This reduction in T1 Gd+ lesions was maintained through week 48 of the study (Table 2). Participants treated with evobrutinib also had reduced annualized relapse rate (ARR) compared with those treated with placebo (Table 1), although this did not reach statistical...
Impel Neuropharma (Seattle, WA) is developing new therapeutic formulations for delivery of therapeutic compounds to the upper nasal cavity with their precision olfactory delivery (POD) device. The POD uses a propellant to deliver drugs to the upper nasal cavity, a new route of administration, which can provide higher bioavailability and rapid uptake vs traditional nasal sprays The POD device is easy to use, requiring only that the nasal tip of the device is inserted into the nostril and squeezed once to activate dose delivery. Coordination of breathing with activation is not required, and...
Emmanuelle A. D. Schindler, MD, PhD; and Christopher Gottschalk, MD
Rashmi B. Halker Singh, MD; Amaal J. Starling, MD; and Juliana VanderPluym, MD
Kate Onorato, MD; Carrie Dougherty, MD, FAHS; and Jessica Ailani, MD, FAHS