Latest News - Epilepsy & Seizure Disorders

Friday, December 07, 2018

Fenfluramine Reduces Seizure Frequency in Patients With Dravet Syndrome

Results of a second phase 3 trial (Study 1504) and an ongoing open-label extension study (Study 1503) of fenfluramine for treatment of patients with Dravet syndrome showed that patients who took low-d…

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Friday, December 07, 2018

Lower Starting Dose of Cenobamate Alleviates Side Effect of DRESS Syndrome

At the American Epilepsy Society annual meeting in New Orleans, LA, results were presented from a large phase 3 safety study of the investigational antiepileptic drug, cenobamate (YKP3089; SK Life Sci…

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Wednesday, December 05, 2018

Perampanel Has Long-Term Convulsive Seizure Freedom, Efficacy at Lower Dose, and Was Recently Approved for Children Age 4 to 12 Years

Recently approved for use in children, age 4 and up, monotherapy or adjunctive treatment with perampanel (Fycompa; Eisai, Woodcliff Lake, NJ) is approved for treatment of partial onset seizures (POS) …

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Wednesday, December 05, 2018

Brivaracetam Efficacy for Treating Acute Seizures in Epilepsy Monitoring Unit

At the American Epilepsy Society Annual Meeting in New Orleans, LA, data were presented from an open-label, randomized, parallel-group, active control study (NCT03021018) and showed brivaracetam (BRV)…

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Tuesday, December 04, 2018

Midazolam Nasal Spray Safety and Efficacy Results Reported

In results presented at the American Epilepsy Society’s annual meeting in New Orleans, LA, midazolam nasal spray (USL261; UCB, Atlanta, GA), a drug being investigated for treatment of acute repe…

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Monday, December 03, 2018

Clobazam Oral Film Provides a Highly Consistent and Easy-to-Give Dose

A new oral-film formulation of clobazam (Sympazan; Aquestive, Warren, NJ) was recently approved by the Food and Drug Administration (FDA) for adjunctive treatment of people with seizures associated wi…

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Sunday, December 02, 2018

Long-Term Seizure Reduction With Responsive Neurostimulation

At the American Epilepsy Society Annual Meeting in New Orleans, LA, results were announced from a 9-year prospective study of treatment with responsive neurostimulation (RNS) (RNS System; NeuroPace, M…

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Sunday, December 02, 2018

Safety and Equivalency of Buccal Film Formulation of Diazepam in Peri-ictal and Interictal Periods

In results presented at the American Epilepsy Society (AES) Annual Meeting in New Orleans, LA, bioavailability and safe administration of a buccal film formulation of 12.5 mg diazepam (Aquestive, Warr…

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Saturday, December 01, 2018

Cannabidiol Has Long-Term Dose-Dependent Efficacy That Does Not Impact Behavior or Depend on Type of SCNA1 Mutation

A pharmaceutical grade, highly purified cannabidiol (CBD) (Epidiolex; Greenwich Biosciences, CA) was recently approved and made available for treatment of patients with seizures related to Lennox-Gast…

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Saturday, December 01, 2018

First Report from North American SUDEP Registry Presented

At the annual meeting of the American Epilepsy Society, data were, for the first time, reported from the North American SUDEP Registry (NASR), a retrospective repository of medical data from persons w…

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Friday, November 30, 2018

Progress in Research for Seizure Prediction

In the 16th Judith Hoyer Lecture on Epilepsy at the annual meeting of the American Epilepsy Society in New Orleans, Michael Privitera, MD, of the University of Cincinnati Gardner Neuroscience Ins…

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Wednesday, November 28, 2018

Biases in Dementia Screening Tools

Brief cognitive tests are useful screening tools for dementia in the primary care setting; however, a study published in the journal Neurology Clinical Practice shows that 3 of the most comm…

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Wednesday, November 14, 2018

Study Confirms Benefits of Laser Interstitial Thermal Therapy

A prospective, multi-center clinical study of 42 patients with brain lesions that recurred after stereotactic radiosurgery (SRS) for metastatic brain tumors showed positive outcomes for lase…

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Monday, November 05, 2018

Clobazam Oral Film Approved For Treatment of Lennox-Gastaut Syndrome

The Food and Drug Administration (FDA) has approved an oral film clobazam (Sympazan; Aquestive Therapeutics, Warren, NJ) for the adjunctive treatment of seizures in patients, age 2 years and up, with …

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Thursday, November 01, 2018

Epidiolex for Dravet Syndrome and Lennox Gastaut Syndrome Available for Prescription

Pharmaceutical grade cannabidiol (CBD) (Epidiolex; Greenwich Biosciences, Carlsbad, CA), approved by the FDA for treatment of patients age 2 and up with Lennox-Gastaut Syndrome (LGS) and Dravet Syndro…

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