Review Identifies Antidepressants and AEDs Effective for Nerve Pain

Friday, March 24, 2017 | Epilepsy & Seizure Disorders , Headache & Pain , Research and Publications


A federal health agency has found certain antidepressants and anti-seizure drugs are among medications that effectively treat diabetic nerve pain. In findings published in the journal Neurology, researchers found moderate evidence in studies and systematic reviews that the antidepressants duloxetine and venlaxine, which act as serotonin-norepinephrine reuptake inhibitors, were effective in reducing neuropathy-related pain. They also found weak evidence that botulinum toxin, the anti-seizure drugs pregabalin and oxcarbazepine, as well as drugs classified as tricyclic antidepressants and atypical opioids were probably effective in reducing pain. Of note, the results showed that while pregabalin works in the same way as gabapentin, the latter was not more effective than placebo.

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