Movement Disorders

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Novel Small Molecule PBT434 Receives Orphan Drug Designation for Treatment of Multiple System Atrophy

Friday, February 01, 2019—The Food and Drug Administration (FDA) has granted orphan drug designation for the molecule PBT434 (Prana Biotechnology LTD,Melbourne, Australia) as a potential treatment for …

First Patient Treated in Phase 3 Study of Ampreloxetine for Neurogenic Orthostatic Hypotension

Tuesday, January 29, 2019—The first patient has been dosed in a registrational phase 3 study (NCT03750552) of ampreloxetine (TD955; Theravance Biopharma, South San Francisco, CA) for treating symptomat…

Continuous Delivery of Levodopa May Decrease Motor Complications of OFF Time

Monday, January 28, 2019—A small open-label study, published in the journal Movement Disorders, compared the efficacy and pharmacokinetics of continuously administered oral levodopa/carbidopa (si…

Valbenazine Reduces Involuntary Movements in Patients with Mood Disorders

Friday, January 18, 2019—A post-hoc analysis of data from a clinical trial of valbenazine (Ingrezza; Neurocrine Biosciences, Inc., San Diego, CA) has been published in the Journal of Affective Di…

First Patients Enrolled in Trial of Wearable Neurostimulation Device for Treating Essential Tremor

Thursday, January 17, 2019—The Pacific Movement Disorders Center at Pacific Neuroscience Institute announced that the first patients have been enrolled into a trial of a wearable, external, and wireless…

Breakthrough Device Designation Granted to Brain-Monitoring Technology

Wednesday, January 09, 2019—The Food and Drug Administration has granted breakthrough device designation to a brain health monitoring technology (Neurametrix; San Francisco, CA). The approved use is moni…

2018 Drug and Device Approvals for Neurology

January 2019—HEADACHE & PAIN Noninvasive Vagus Nerve Stimulation (Gammacore; electroCore, Basking Ridge, NJ) Cleared: November 28, 2018 and January 29, 2018 Indications: adjun…

Cognitive Complaints and Neuropsychologic Testing

Nabil Ali, MD; Kendra Corning, PsyD, HSPP; and Laura M. Clark, PhD, ABPP

January 2019—When should neuropsychologic tests be ordered and what questions should testing answer?


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