Epilepsy & Seizures

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Lower Starting Dose of Cenobamate Alleviates Side Effect of DRESS Syndrome

Friday, December 07, 2018—At the American Epilepsy Society annual meeting in New Orleans, LA, results of a large, phase 3 safety study of the investigational antiepileptic drug, cenobamate (YKP3089; SK…

Fenfluramine Reduces Seizure Frequency in Patients With Dravet Syndrome

Friday, December 07, 2018—Results of a second phase 3 trial (Study 1504) and an ongoing open-label extension study (Study 1503) of fenfluramine for treatment of patients with Dravet syndrome showed tha…

Brivaracetam Efficacy for Treating Acute Seizures in Epilepsy Monitoring Unit

Wednesday, December 05, 2018—At the American Epilepsy Society Annual Meeting in New Orleans, LA, data were presented from an open-label, randomized, parallel-group, active control study (NCT03021018) show…

Perampanel Has Long-Term Convulsive Seizure Freedom, Efficacy at Lower Dose, and Was Recently Approved for Children Age 4 to 12 Years

Wednesday, December 05, 2018—Recently approved for use in children, age 4 and up, monotherapy or adjunctive treatment with perampanel (Fycompa; Eisai, Woodcliff Lake, NJ) is approved for treatment of part…

Midazolam Nasal Spray Safety and Efficacy Results Reported

Tuesday, December 04, 2018—In results presented at the American Epilepsy Society’s annual meeting in New Orleans, LA, midazolam nasal spray (USL261; UCB, Atlanta, GA), a drug being investigated fo…

Clobazam Oral Film Provides a Highly Consistent and Easy-to-Give Dose

Monday, December 03, 2018—A new oral-film formulation of clobazam (Sympazan; Aquestive, Warren, NJ) was recently approved by the Food and Drug Administration (FDA) for adjunctive treatment of people wi…

Safety and Equivalency of Buccal Film Formulation of Diazepam in Peri-ictal and Interictal Periods

Sunday, December 02, 2018—In results presented at the American Epilepsy Society (AES) Annual Meeting in New Orleans, LA, bioavailability and safe administration of a buccal film formulation of 12.5 mg …

Long-Term Seizure Reduction With Responsive Neurostimulation

Sunday, December 02, 2018—At the American Epilepsy Society Annual Meeting in New Orleans, LA, results were announced from a 9-year prospective study of treatment with responsive neurostimulation (RNS) …


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Launched in 2002, Practical Neurology is a publication uniquely dedicated to presenting current approaches to patient management, synthesis of emerging research and data, and analysis of industry news with a goal to facilitate practical application and improved clinical practice for all neurologists. Our straightforward articles give neurologists tools they can immediately put into practice.