Alzheimer’s & Dementia

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Funding Received for Phase 2 Trial of Xanomeline-Tropsium Chloride

Wednesday, August 08, 2018—A $42-million financing round has been completed and will be used to finance a phase 2 trial of xanomeline-tropsium chloride (KarXT; Karuna, Boston, MA) for treatment of perso…

Braintest App Has Equivalent Sensitivity and Specificity as SAGE Test for Mild Cognitive Impairment

Tuesday, August 07, 2018—There is an app (BrainTest, Columbus, OH) used to detect mild cognitive impairment (MCI). It is a clinically validated, digital version of the paper and pen Self-Administered …

Aggressive Treatment of Hypertension Promotes Healthy Brains and Hearts

Monday, July 30, 2018—Aggressive lowering of systolic blood pressure (BP) reduces the risk of mild cognitive impairment (MCI) and combined MCI and dementia. In the SPRINT trial (NCT01206062), 2 str…

Breaching the Blood-Brain Barrier: A Potential New Treatment Modality

Monday, July 30, 2018—In a small, yet groundbreaking, clinical trial, MR-guided focused ultrasound (MRgFUS) (ExablateNeuro; Insightec, Miami FL) was used to open the blood-brain barrier (BBB) safel…

Positive Results in Phase 2 Trial of BAN2401 for Treatment of Persons With Alzheimer’s Disease

Friday, July 27, 2018—Detailed results of a phase 2 study (NCT01767311) of BAN2401 (Eisai, Woodcliff Lake, NJ and Biogen, Cambridge, MA) were presented at the Alzheimer's Association Internatio…

Phase 2/3 Clinical Trial of Trigriluzole for Alzheimer's Disease Initiated

Thursday, July 26, 2018—A Phase 2/3 clinical trial of trigriluzole (BHV-4157; Biohaven, Cambridge, MA for treatment of patients with mild-to-moderate Alzheimer's disease (AD) has been initiated i…

Crenezumab and Gantenerumab In Phase 3 Trials for Treating Persons with Alzheimer’s Disease

Thursday, July 26, 2018—Crenezumab and Gantenerumab are 2 monoclonal antibodies directed against amyloid-ß (Aß) soluble and oligomeric forms. Crenezumab more specifically targets oli…

Gut Bacteria and Lipid Metabolism May Influence Alzheimer’s Disease and Dementia

Wednesday, July 25, 2018—Several studies at the Alzheimer’s Association International Conference (AAIC) 2018 showed that lipid, cholesterol, and bile acid metabolism correlate with biomarkers fo…

 
 

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